They are competing in a survivalist reality show called "Apocalypse:
Ultimate Survivalist" with a theme that it takes place at the end of the
world. Like the original Wrong Turn, it is set in the West Virginia
back-country. The show is hosted by retired military commander, Dale
Murphy (Rollins), who makes them give up all outside communication
before starting. After Kimberly doesn't show up, the show's producer
Mara steps into her place. As they move into the forest, the surviving
cannibal, "Three Finger" from the first movie attacks and kills Neil,
one of the producers, by slicing off a large portion of his scalp.
Afterward, another cannibal called "Pa" punctures Dale's ATV tires with
arrows, preventing him from escaping. Dale then throws a knife that hits
"Three-Finger" in the chest, who pulls it out and licks the blood from
it. Dale turns around only to be knocked out by "Pa".
Later, Michael, Mara's boyfriend, tries to create "sparks" between
Elena and Jake by getting Elena to reveal her breasts to him on camera. Jake doesn't like the
fact that Elena is stripping and refuses to
engage in any sexual activity because
of his morals. He then leaves to look for food in the woods. Elena then
turns to Michael and decides to perform a "persuading" blowjob, and has oral sex
with him while Mara and Nina watch in disgust. Mara is devastated, then
she goes with Nina to a cabin in search of a phone. There they witness a
cannibal, "Ma", giving birth, and are in turn spotted by "Sister". The
girls get out of the cabin through a dug out trench as "Sister" kicks
down the door. The two run away into the woods with the cannibals
chasing them. During the pursuit, Mara is hit in the head with an axe
and killed as Nina hides. One of the cannibals, "Pa," looks for her but
doesn't find her. The other cannibals drive up with Mara tied to the
hood of their truck and the cannibal gets in and drives off. Nina sets
off to find the others.
Down by the lake, Michael goes back to the RV and Elena stays there
to tan in her
underwear. "Brother", watching her in the
bushes, starts masturbating but is interrupted by "Sister" who is
furious and jealous of Elena. "Sister" knocks him over and he sets off
an alarm. Elena hears it and starts to get dressed. "Sister" runs out of
the bushes towards Elena, who trips and falls into the lake. "Sister"
slashes her across the back with a machete repeatedly, killing her. She
stops hacking at the body when "Brother" comes out of the bushes.
"Sister" suddenly becomes passive and lovingly caresses "Brother"'s
face. She then kisses him.
Back at the RV, Michael is stabbed with an arrow, taken to the
cannibals' home, and later decapitated. As Three-Finger tortures Dale,
who is suspended upside-down, he uses a moment to his advantage, manages
to escape, and shoots the mutant with a shotgun.
Jake finds Amber and Jonesy at a barbecue pit. As they eat the
discovered meat, a crazed Nina races up and tells her story. Jake then
realizes it was Kimberly's leg that they had been eating after spotting
her signature snake tattoo. As they run, Dale finds "The Old Man" (same
old man and actor from previous movie) in his cabin. Dale tells him
about the cannibals and soon realizes the man is their un-mutated
father. After a brief skirmish, Dale kills the old man by blowing him up
with a stick of dynamite.
After Amber, Jonesy, Jake, and Nina notice that the RV is gone, they
run towards the woods and hear moaning sounds. They believe that
"Brother" is raping Elena. Jake gets up to intervene, and it is revealed
that the woman is actually "Sister" wearing Elena's hair (obviously
scalped from Elena's head). Nina runs, horrified, and falls into a trap
set by the cannibals. Amber, Jonesy and Jake fight the cannibals and
"Brother" falls and punctures his head on a rock. Amber, Jonesy, and
Jake look for Nina. Jake decides to look for her while Amber and Jonesy
go for Help. Jake finds Nina in the trap hole and runs towards the
river, where "Sister" finds them and shoots at them as they jump to the
river. After a chase, Amber and Jonesy get caught in a trap and are soon
killed with a single dual headshot arrow. Meanwhile, Nina and Jake make
it to the mill. They walk through the first gate and Nina sees a tank
with a toxic symbol. Jake and Nina then enter the mill and search
around. They hear a truck and make their way to a view of a garage
filled with stolen empty cars. They hear Michael screaming and Jake arms
himself whilst Nina waits outside the RV. Jake enters the RV and
realizes that Michael's screams weren't coming from the RV, but from
somewhere close. Jake then watches via live feed Michael being
decapitated. As Nina waits outside the van, she hears a giggle and
"Sister" appears. Nina is then dragged away. Jake screams to her, but
when he turns around, "Pa" is standing there. Jake hits "Pa" with a
monkey wrench, but "Pa" shakes it off and easily overpowers him.
The abandoned mill is revealed to be the mutant's home, and Dale
managed to sneak into the compound. The family of mutants appear to
function and take part in certain activities like any normal family such
as watching television together and saying grace before eating. Jake is
held captive while Nina is strapped to a chair lined with barbed wire
at the table. While sneaking, Dale catches in a noisy trap, alerting the
family who soon chase him. He manages to kill "Brother" and "Sister"
with dynamite stuck to an arrow and goes to Nina and Jake. He frees Nina
and, while helping Jake, is shot in the back with an arrow and is then
killed by a razor-wire chain thrown around his throat. Nina successfully
escapes, however Jake wanders into a room where an enormous tree
de-barker is kept, and soon gets into a fight with "Pa". Nina returns to
the mill and meets up with Jake, who killed "Ma" and "Pa" by pushing
them into the de-barker. They then find Kimberly's abandoned car and
drive away to safety.
As the film ends, the still alive Three-Finger feeds the newborn
mutant baby Mara's finger and a bottle filled with a greenish chemical waste. His laugh is heard over the end credits.